As you probably know, the newest iMacs come with FrontRow, an app that makes the computer look like a large iPod and lets you play music and videos from across the room with the included remote. MediaCentral is what Chuck Joiner calls ?FrontRow for the rest of us?. MediaCentral looks almost exactly like FrontRow, and it is said to work with a remote control, but I don't have one to test it with. I listened to Chuck's podcast interview with the makers of MediaCentral, and they mentioned that it can also play music from Shared iTunes libraries, which FrontRow can't do.
Update: This program is no longer free. Bummer. Another one bites the dust.